Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT)
Authors' conclusion
Randomisation to a successful intensive weight loss intervention, including regular physical activity encouragement, was not associated with increased physical activity although sleep parameters improved. Physical activity was greater, and night-time waking reduced in those who maintained >10% weight loss at 12 and 24 months.
Study context
- Population
- Participants with T2D in the DiRECT trial; wrist-worn GENEActiv accelerometer for 7 days at baseline, 12 and 24 months
- Participants
- 66 vs 104
- Comparison
- Dietary weight management programme vs best-practice care
- Interventionn = 66
- Controln = 104reference
- Primary endpoint
- Physical activity, inactivity and sleep
- Follow-up
- Baseline, 12 and 24 months
Methodological detailsexploratory analysis, objective accelerometer measurement
- Exploratory analysis
- Objective accelerometer measurement
Primary result
As reported in the abstract
Total physical activity and inactivity · any time point
- No differences in total physical activity or inactivity, intervention vs control, at any time point, despite average weight loss of 10 kg at 12 months with intervention
Further findings
Daily acceleration, ≥10% vs <10% weight loss · 24 months
P = 0.020
Acceleration in most active 5-hour period, ≥10% vs <10% weight loss · 24 months
P = 0.023
| Outcome | Difference (mins/day) | P value |
|---|---|---|
| Light activity, ≥10% vs <10% weight loss (exploratory) · 24 monthsMore light activity with ≥10% · exploratory analysis | 11 | P = 0.033 |
- Bouts of Inactivity30min, ≥10% vs <10% weight loss (exploratory) · 12 and 24 months · significantly lower with ≥10% · exploratory analysis
- interaction, p = 0.005
Wakefulness after sleep onset · 12 and 24 months
- Decreased in intervention vs control and in the ≥10% weight loss group
Original publication
Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabet Med. Published 29 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →