Estimated glucose disposal rate outperforms thirteen other insulin resistance indices in predicting new-onset cardiometabolic multimorbidity: a longitudinal study from the china health and retirement longitudinal study (CHARLS) and cross-sectional replication from the national health and nutrition examination survey (NHANES)

Authors' conclusion

Across both the Chinese and U.S. study populations, statistically significant and independent associations with CMM were consistently observed for all 14 evaluated IR indices. Among these, eGDR consistently demonstrated the most superior discriminatory performance and risk reclassification capability across longitudinal and cross-sectional settings, single time-point and cumulative assessments, and ethnically distinct populations, supporting its adoption as a preferred, clinically accessible marker for CMM risk stratification. The convergent findings across two large, nationally representative populations of distinct ethnic backgrounds further underscore the cross-population generalizability of eGDR and its potential translational utility in diverse clinical settings.