Greater Glycaemic Responses to Bodyweight Change in South Asians Than White Europeans at High Risk of Type 2 Diabetes
Authors' conclusion
Bodyweight changes have a greater adverse impact on glycaemic control in South Asian populations at high risk of type 2 diabetes, driven by stronger associations with post-challenge glucose
Study context
- Population
- Adults at high risk of T2D, UK PROPELS trial, with ≥2 bodyweight and oral glucose tolerance test (OGTT) observations
- Participants
- 543 adults
- Comparison
- South Asian vs White European
- South Asiann = 172
- White Europeann = 371reference
- Primary endpoint
- Ethnicity interaction in the association between bodyweight change and change in HbA1c and OGTT-derived measures
- Follow-up
- Baseline, 1 and 4 years
Methodological detailscohort analysis, trial arms analysed as a single cohort, generalised estimating equation models
- Cohort analysis
- Trial arms analysed as a single cohort
- Generalised estimating equation models
Primary result
As reported in the abstract
Change in HbA1c per 5 kg change in bodyweight
South Asian
1.5
CI 1.0–2.0 · mmol/mol
White European
0.9
CI 0.6–1.3 · mmol/mol
p for ethnicity interaction = 0.034
Further findings
mmol/L
| Outcome | South Asian | White European | P value |
|---|---|---|---|
| Change in 2-h post-challenge glucose per 5 kg change in bodyweight | 0.9 | 0.4 | P = 0.003 for ethnicity interaction |
Fasting glucose and insulin measures
- No ethnicity interactions were observed for fasting glucose or insulin measures
Original publication
Greater Glycaemic Responses to Bodyweight Change in South Asians Than White Europeans at High Risk of Type 2 Diabetes. Diabetes Obes Metab. Published 1 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →