Subtypes of Type 2 Diabetes and Prediabetes: Mortality and Excess Life Lost in South Asians
Authors' conclusion
Insulin-deficient subtypes made up a high proportion of individuals with T2D and prediabetes and were associated with higher mortality hazards and excess years of life lost.
Study context
- Population
- South Asian participants of the CArdiometabolic Risk Reduction cohort; 2,639 with T2D and 4,992 with prediabetes
- Participants
- 14,036 participants
- Exposure
- Data-driven subtypes of T2D and prediabetes vs normal glucose tolerance
- Outcome
- All-cause and CVD mortality and excess years of life lost
- Follow-up
- Median 10.6 years
Methodological detailsunsupervised k-means clustering (age, BMI, HbA1c, insulin resistance, β-cell dysfunction)
- Unsupervised k-means clustering (age, BMI, HbA1c, insulin resistance, β-cell dysfunction)
Main finding
As reported in the abstract
All-cause mortality
Each group vs normal glucose toleranceHazard ratio (95% CI)
SIDD
3.34(2.39–4.68)
MIDD
1.39(1.05–1.84)
SIRD
1.67(1.15–2.41)
IDPD
1.32(1.03–1.68)
- Deaths
- 1,076
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD mortality · median follow-up 10.6 yearsIDPDvs Normal glucose tolerance | 1.53 (1.00–2.34) | |
| 0.512Hazard ratio (log scale) |
Excess years of life lost vs normal glucose tolerance
- Cardiovascular disease (CVD) mortality — CVD deaths
- 405
CVD mortality · median follow-up 10.6 years
- Insulin-resistant prediabetes (IRPD) was not associated with increased CVD mortality
Original publication
Subtypes of Type 2 Diabetes and Prediabetes: Mortality and Excess Life Lost in South Asians. Diabetes Care. Published 8 May 2026. doi:10.
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