Effects of exercise training on bone health in elderly people with type 2 diabetes without osteoporosis: A randomised clinical trial
Authors' conclusion
A two-year exercise training improved several non-invasive measures of bone health, together with muscle and physical function parameters, potentially reducing fracture risk in people with type 2 diabetes.
Study context
- Population
- Elderly individuals with T2D without osteoporosisrandomized 1:1
- Participants
- 200 individuals
- Comparison
- Two-year exercise training program vs standard care
- Primary endpoint
- Coprimary: Trabecular bone score (TBS) (surrogate measure of bone quality) and bone mineral density (BMD) at three sites
- Follow-up
- Two years
Methodological detailsrandomized 1:1
- Randomized 1:1
Primary result
As reported in the abstract
Exercise vs ControlEstimate (95% CI)P value
Disappeared after adjusting for abdominal fat indices
mean between-group difference, TBS 0.016(0.011–0.021)
P < 0.0001Exercise
between-group difference, lumbar spine BMD 0.014(0.005–0.024)
P = 0.004Exercise
between-group difference, femoral neck BMD 0.017(0.006–0.028)
P = 0.003Exercise
between-group difference, total hip BMD 0.020(0.010–0.030)
P = <0.0001Secondary outcomes
Other bone measures, body composition, muscle strength and quality, physical performance, cardiorespiratory fitness
- Significant between-group differences also observed
Safety
- No between-group differences in adverse events
Original publication
Effects of exercise training on bone health in elderly people with type 2 diabetes without osteoporosis: A randomised clinical trial. Diabetes Res Clin Pract. Published 6 May 2026. doi:10.
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