Optimal dose and exercise modality to improve HbA1c in older adults with type 2 diabetes mellitus: a systematic review with pairwise, network, and dose–response meta-analyses
Study context
- Population
- Older adults with T2D in RCTs of exercise interventions reporting HbA1c
- Comparison
- Exercise modalities vs control
- Outcome
- HbA1c
Methodological detailsBayesian network meta-analysis, dose–response network meta-analysis, Three databases searched
- Bayesian network meta-analysis
- Dose–response network meta-analysis
- Three databases searched
Pooled result
As reported in the abstract
Each group vs controlMD, % (95% CrI)
HIIT
−0.95(−1.45 to −0.49)
CE
−0.59(−0.93 to −0.25)
CAE
−0.46(−0.69 to −0.24)
MBE
−0.42(−0.76 to −0.10)
RT
−0.29(−0.51 to −0.08)
Further pooled results
Dose–response: overall exercise dose and HbA1c reduction
- Non-linear association; maximal estimated benefit at approximately
- 704 METs-min/week
- 95% CrI excluding zero between
- 241 and 920 METs-min/week
- High-intensity interval training (HIIT) showed the steepest estimated dose–response relationship, with wider CrIs
- Other modalities showed more gradual dose–response patterns across their estimated effective ranges
Original publication
Optimal dose and exercise modality to improve HbA1c in older adults with type 2 diabetes mellitus: a systematic review with pairwise, network, and dose–response meta-analyses. Diabetes Res Clin Pract. Published 21 August 2026. doi:10.
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