Trends and disparities in population-based cerebrovascular disease–related mortality involving diabetes in the United States (1999–2023) and forecasts to 2035: a CDC WONDER analysis
Authors' conclusion
Population-based CeVD-related mortality involving DM improved early but worsened around the COVID-19 period.
Study context
- Population
- US adults aged ≥25 years, deaths involving both cerebrovascular disease (ICD-10 I60-I69) and diabetes mellitus (DM) (E10-E14), 1999–2023
- Participants
- 827,181 deaths
- Outcome
- Population-based crude and age-adjusted mortality rates (AAMRs) per 100,000 of CeVD-related mortality involving DM, and their trends
- Follow-up
- 1999–2023
Methodological detailspopulation-based, CDC WONDER Multiple Cause of Death data, Joinpoint regression, exploratory ETS and ARIMA forecasts to 2035
- Population-based
- CDC WONDER Multiple Cause of Death data
- Joinpoint regression
- Exploratory ETS and ARIMA forecasts to 2035
Main finding
As reported in the abstract
CeVD-related mortality involving DM
DM-related deaths also involving cerebrovascular disease (CeVD)
827,181 (42.03%) of 1,968,204
Observational data: associations, not effects.
Further findings
Demographic and geographic disparities
- Younger adults showed less favorable trends
- Non-Hispanic Black adults, the South and nonmetropolitan areas remained disproportionately affected
Forecasts to 2035
- Exploratory ETS and ARIMA models suggested possible renewed increases by 2035, with widening prediction intervals
Original publication
Trends and disparities in population-based cerebrovascular disease–related mortality involving diabetes in the United States (1999–2023) and forecasts to 2035: a CDC WONDER analysis. Diabetes Res Clin Pract. Published 21 August 2026. doi:10.
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