Trends in Type 2 Diabetes Mellitus and Parkinson’s Disease Related Mortality in the United States from 1999 to 2020
Authors' conclusion
T2DM and PD-related mortality has surged over the past two decades, particularly since 2015, with significant racial, sex-based, and regional disparities. Targeted public health strategies are needed to address these growing health concerns.
Study context
- Population
- US residents aged 65 + with T2DM (ICD-10: E11) and Parkinson's Disease (PD) (ICD-10: G20) related deaths, 1999–2020
- Participants
- 26,020 deaths
- Outcome
- T2DM- and PD-related AAMR per 100,000 and APC
- Follow-up
- 1999 to 2020
Methodological detailsCDC WONDER database, Joinpoint regression
- CDC WONDER database
- Joinpoint regression
Main finding
As reported in the abstract
AAMR (T2DM and PD related)
Age-adjusted mortality rates (AAMR) in 1999
1.65
AAMR in 2020
5.61
Annual percent change (APC) 2015–2020
+14.42 %
95 % CI: 11.22 to 20.80
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| AAMR by sex | Males 4.51 · Females 1.80 |
| AAMR by race/ethnicity | Hispanic or Latino 3.61 · Non-Hispanic Black 1.96 |
| AAMR by urbanization | Non-metropolitan 3.64 · Metropolitan 2.71 |
- AAMR by race/ethnicity: highest (Hispanic or Latino) and lowest (non-Hispanic Black) across racial groups
Original publication
Trends in Type 2 Diabetes Mellitus and Parkinson’s Disease Related Mortality in the United States from 1999 to 2020. Diabetes Res Clin Pract. Published 8 May 2025. doi:10.
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