Single-cell profiling of pancreatic islets maps subtype-associated molecular alterations in type 2 diabetes
Authors' conclusion
Our study provides an exploratory single-cell map of subtype-associated transcriptomic patterns in pancreatic islets across clinically defined type 2 diabetes subgroups.
Study context
- Population
- Pancreatic islet donors with T2D (43) and healthy controls; scRNA-seq of 131,083 cells from 32 donors43 T2D donors
- Comparison
- T2D subtypes vs healthy controls
- Outcome
- Subtype-associated islet molecular alterations
Methodological detailssingle-cell RNA sequencing, external centroid validation
- Single-cell RNA sequencing
- External centroid validation
Main finding
As reported in the abstract
Subtype mapping sensitivity, full dataset
85.0% to 100.0%
Subtype mapping sensitivity, scRNA-seq sub-cohort
91.7% to 100.0%
Original publication
Single-cell profiling of pancreatic islets maps subtype-associated molecular alterations in type 2 diabetes. Diabetologia. Published 1 September 2026. doi:10.
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