Identification of Frailty Subtypes in A frican A merican Adults With and Without Type 2 Diabetes: A Latent Class Analysis From the J ackson H eart S tudy
Authors' conclusion
Three heterogeneous frailty subgroups were identified among African American adults, with similarities and differences noted for those with and without diabetes with regard to high probabilities for certain deficits in health and functional outcomes.
Study context
- Population
- African American men and women enrolled in the Jackson Heart Study at baseline (Exam1: 2000–2004); 25 age-related deficits in health and functional outcomes as indicators
- Participants
- 3,979 men
- Exposure
- Adults with vs without diabetes
- Outcome
- Frailty subtypes (latent classes)
- Follow-up
- Baseline
Methodological detailsmultiple-group latent class analysis, diabetes status as grouping variable
- Multiple-group latent class analysis
- Diabetes status as grouping variable
Main finding
As reported in the abstract
Frailty subtypes: three classes identified
Severely frail
Moderately frail
Not frail
Observational data: associations, not effects.
Further findings
Deficit profiles of frailty classes
- Severely frail: higher probabilities of poor health perception, limited mobility, high blood pressure, obesity and claudication, similar with and without diabetes
- Moderately frail with diabetes: higher probabilities of poor health perception, limited mobility, high blood pressure, obesity and claudication
- Moderately frail without diabetes: only sleep quality and obesity had higher probabilities
Original publication
Identification of Frailty Subtypes in A frican A merican Adults With and Without Type 2 Diabetes: A Latent Class Analysis From the J ackson H eart S tudy. Diabetes Obes Metab. Published 1 June 2026. doi:10.
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