The Association of Adiposity and Renin-angiotensin-aldosterone System (RAAS) With Incident Diabetes in African Americans: The Jackson Heart Study
An erratum to this article was published (J Clin Endocrinol Metab, 18 Dec 2024 ↗)
Authors' conclusion
Higher aldosterone in participants is associated with greater risk of diabetes, particularly among individuals with prediabetes and lower WC.
Study context
- Population
- African American adults without diabetes at baseline (2000–2004), Jackson Heart Study554 incident cases
- Participants
- 3,219 adults
- Exposure
- Combined RAAS and adiposity measures and their interactions
- Outcome
- Incident diabetes
- Follow-up
- Median 7.5 years
Methodological detailslongitudinal, adjusted for age, sex, education, occupation, systolic BP, smoking, physical activity and RAAS-altering medications
- Longitudinal
- Adjusted for age, sex, education, occupation, systolic BP, smoking, physical activity and RAAS-altering medications
Main finding
As reported in the abstract
- Aldosterone, WC and LAR positively associated with incident diabetes
- all P < .05
Observational data: associations, not effects.
Further findings
WC*aldosterone interaction by glycaemic status
- Interaction significant in participants with prediabetes but not in those with normoglycemia
Original publication
The Association of Adiposity and RAAS With Incident Diabetes in African Americans: The Jackson Heart Study. J Clin Endocrinol Metab. Published 17 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →