Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia
Authors' conclusion
Insulin sensitivity, secretion, and clearance differ significantly in normoglycemic African American versus European American offspring of parents with type 2 diabetes and are associated with the risk of incident dysglycemia.
Study context
- Population
- Initially normoglycemic offspring of parents with T2D (Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study) who completed IVGT and HEC at baseline; 72% women; mean age 44.6±10.1 years
- Participants
- 268 participants
- Exposure
- African American vs European American offspring of parents with T2D; insulin measures as predictors of incident dysglycemia
- African Americann = 145
- European Americann = 123reference
- Outcome
- Incident dysglycemia
- Follow-up
- 5.5 years
Methodological detailsbiracial cohort, 5.5-year follow-up
- Biracial cohort
- 5.5-year follow-up
Main finding
As reported in the abstract
Predictors of incident dysglycemia (Cox proportional hazards models)
- Developed incident dysglycemia
- 91 of 268
- Maintained normoglycemia
- 177
- Insulin secretion, HR (95% CI 0.996 to 0.999), p=0.005
- 0.997
- Insulin sensitivity, HR (95% CI 0.913 to 0.984), p=0.005
- 0.948
- Disposition index (DI), HR (95% CI 0.909 to 0.983), p=0.005
- 0.945
- Basal insulin clearance, HR (95% CI 1.005 to 1.056), p=0.018
- 1.030
Observational data: associations, not effects.
Further findings
Baseline insulin measures by ethnicity
- African American offspring had higher insulin secretion and DI, and lower insulin sensitivity and clearance, than European American
Baseline glycemia (all participants)
- FPG, mg/dL (mean±SD)
- 91.9±6.91
- 2-hour plasma glucose, mg/dL (mean±SD)
- 123±25.1
Original publication
Insulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia. BMJ Open Diabetes Res Care. Published 23 December 2024. doi:10.
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