Ethnic differences in the relationship between ectopic fat deposition and insulin sensitivity in Black African and White European men across a spectrum of glucose tolerance
Authors' conclusion
The present study suggests that BA and WE men exhibit the same degree of IR across a glucose tolerance continuum, but with lower VAT and IHL levels in the BA population, suggesting that IR may be driven by a mechanism other than increased ectopic fat accumulation in BA men.
Study context
- Population
- Black African and White European men across a spectrum of glucose tolerance (NGT, IGT, T2D)
- Participants
- 48 vs 53
- Exposure
- Black African (BA) vs White European (WE) men across NGT, IGT and T2D
- BAn = 48
- WEn = 53reference
- Outcome
- Relationship between ectopic fat (VAT, IHL) and tissue-specific (hepatic, peripheral, adipose tissue) IR
Methodological detailstwo-step hyperinsulinaemic-euglycaemic clamp with stable isotopes, MRI-measured fat depots
- Two-step hyperinsulinaemic-euglycaemic clamp with stable isotopes
- MRI-measured fat depots
Main finding
As reported in the abstract
- Visceral adipose tissue (VAT) and intrahepatic lipid (IHL) associated with hepatic insulin resistance (IR) in BA
- p = 0.001
- VAT and IHL associated with peripheral IR in WE
- p = 0.027
Observational data: associations, not effects.
Original publication
Ethnic differences in the relationship between ectopic fat deposition and insulin sensitivity in Black African and White European men across a spectrum of glucose tolerance. Diabetes Obes Metab. Published 16 August 2024. doi:10.
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