Metabolic clearance rate of insulin across the glucose tolerance spectrum by race and ethnicity in youth with obesity
Authors' conclusion
Higher FI concentrations in the presence of dysglycemia despite β-cell failure could be explained by decreased MCRI. Racial and ethnic contrast in insulin dynamics differs by glycemic status and is more pronounced in dysglycemia manifested by lower MCRI and heightened first-phase insulin secretion in Black versus White youth.
Study context
- Population
- Youth with obesity across the glucose tolerance spectrum, by race and ethnicity
- Participants
- 206 participants
- Exposure
- Normal glucose tolerance (NGT) vs IGT vs T2D; Black vs White youth
- Outcome
- Metabolic clearance rate of insulin (MCRI)
Main finding
As reported in the abstract
- T2D vs NGT: P < 0.001
- T2D vs NGT: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| MCRI by race (Black vs White youth)Black vs White · MCRI lower in Black youth | P < 0.001 |
| MCRI by race (Black vs White youth)Black vs White | P < 0.001 |
- Metabolic clearance rate of insulin (MCRI) by race (Black vs White youth): MCRI lower in Black youth with dysglycemia; not in those with NGT
Correlates of MCRI
- MCRI correlated inversely with fasting insulin (FI) and adiposity measures, and directly with peripheral insulin sensitivity (PIS) and disposition index
Insulin dynamics in Black vs White youth with dysglycemia
- Lower PIS, lower MCRI and higher first-phase insulin secretion in Black vs White youth with dysglycemia
Original publication
Metabolic clearance rate of insulin across the glucose tolerance spectrum by race and ethnicity in youth with obesity. Obesity (Silver Spring). Published 5 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →