Adipose Tissue‐Derived Small Extracellular Vesicles in Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance
Authors' conclusion
Distinct molecular signatures in sEVAT offer a unique insight into AT dysfunction during IGT and offer novel diagnostic and therapeutic targets.
Study context
- Population
- Individuals with normal GT (NGT) or impaired GT (IGT); plasma adipose tissue (AT)-derived small extracellular vesicles (sEVAT) isolated at fasting (0 h) and 1 h after oral glucose tolerance test (OGTT) glucose challenge
- Participants
- 5 vs 5
- Comparison
- IGT vs NGT
- IGTn = 5
- NGTn = 5reference
- Outcome
- Biophysical and molecular profiles of sEVAT
Methodological detailsC2C12 myotubes treated with sEVAT for 48 h; 84 insulin signaling-related genes quantified
- C2C12 myotubes treated with sEVAT for 48 h; 84 insulin signaling-related genes quantified
Main finding
As reported in the abstract
- Size and concentration of sEVAT did not differ between groups
- INSRα expression on sEVAT comparable at fasting; opposite directional changes between groups at 1-h OGTT
- LC-MS/MS identified significant proteomic differences between NGT and IGT sEVAT
- miR-27a-5p and miR-145a-5p levels in sEVAT differed significantly by glucose tolerance (GT) status
- sEVAT (IGT-0 h) significantly downregulated insulin signaling-related genes in C2C12 myotubes
Original publication
Adipose Tissue‐Derived Small Extracellular Vesicles in Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance. Obesity (Silver Spring). Published 22 February 2026. doi:10.
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