In humans increase in intrapancreatic adipose tissue predicts beta-cell dedifferentiation score before diabetes onset: A pilot study
An erratum to this article was published (Diabetes Res Clin Pract, Jul 2025 ↗)
Authors' conclusion
The accumulation of WAT might be responsible for dedifferentiation, making it a potential new target to curb diabetes onset.
Study context
- Population
- Patients without history of diabetes with pancreatic samples, who had previously undergone OGTT and hyperglycemic clamp
- Comparison
- NGT vs IGT vs nDM
- Outcome
- Relation between intrapancreatic fat (WAT) and β-cell dedifferentiation prior to diabetes onset
Main finding
As reported in the abstract
| Group | Value | Dedifferentiation score |
|---|---|---|
| NGT | 4.43 ± 4.37 % | 4.8 ± 3.8 |
| IGT | 10.67 ± 8.5 % | 32.37 ± 7.4 |
| nDM | 43.79 ± 20.83 % | 40.38 ± 19 |
Value
NGT4.43 ± 4.37 %
IGT10.67 ± 8.5 %
nDM43.79 ± 20.83 %
Dedifferentiation score
NGT4.8 ± 3.8
IGT32.37 ± 7.4
nDM40.38 ± 19
- Linear regression: WAT predicted dedifferentiated β-cells
- R = 0.86, p = 0.005
- Predicted increase in dedifferentiated β-cells per one-point change in WAT
- 1.25 points
Further findings
Relation to 1-hour post-load glycemia
- WAT and dedifferentiation score pair significantly related to 1-hour post-load glycemia
Original publication
In humans increase in intrapancreatic adipose tissue predicts beta-cell dedifferentiation score before diabetes onset: A pilot study. Diabetes Res Clin Pract. Published 10 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →