Altered GIP/GLP-1 Secretion Ratio is Associated With Impaired β Cell Function in Humans
Authors' conclusion
Our findings demonstrate that, despite similar GIP and GLP-1 secretion, the GIP/GLP-1 SR declines as glucose tolerance deteriorates, reflecting an imbalance in incretin dynamics rather than absolute hormone secretion. This imbalance may indicate early β cell dysfunction and chronic incretin resistance.
Study context
- Population
- Subjects with unknown history of T2D, not on antidiabetic treatments, classified by OGTT; mixed meal test (MMT) and euglycemic hyperinsulinemic clamp
- Participants
- 60 subjects
- Exposure
- Normal glucose tolerance (NGT) vs impaired glucose tolerance (IGT) vs diabetes mellitus (DM)
- NGTn = 23reference
- IGTn = 16
- DMn = 21
- Outcome
- GIP/GLP-1 secretion ratio (SR) and its areas under the curve during MMT, and association with β cell function
Main finding
As reported in the abstract
GIP/GLP-1 secretion during MMT
- Similar GIP and GLP-1 responses to MMT among the 3 groups (linear mixed model)
- GIP/GLP-1 secretion ratio (SR) reduced in DM vs NGT and IGT
- Multiple regression: predictive role of GIP/GLP-1 SR on rate sensitivity and standardized insulin secretion at 5 mmol/L
Observational data: associations, not effects.
Original publication
Altered GIP/GLP-1 Secretion Ratio is Associated With Impaired β Cell Function in Humans. J Clin Endocrinol Metab. Published 12 May 2025. doi:10.
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