Disposition Index (DI)/cle, a Measure Consisting of Insulin Sensitivity, Secretion, and Clearance, Captures Diabetic States
Authors' conclusion
DI/cle can serve as a new indicator for the trajectory of changes in glucose tolerance.
Study context
- Population
- Subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and T2D undergoing hyperglycemic clamp, hyperinsulinemic-euglycemic clamp and oral glucose tolerance test (OGTT)
- Participants
- 47 / 16 / 49
- Comparison
- NGT vs IGT vs T2D
- NGTn = 47
- IGTn = 16
- T2DMn = 49
- Outcome
- Relation of blood glucose to insulin sensitivity, secretion and clearance
Methodological detailsretrospective mathematical analysis, hyperglycemic clamp, hyperinsulinemic-euglycemic clamp and OGTT
- Retrospective mathematical analysis
- Hyperglycemic clamp, hyperinsulinemic-euglycemic clamp and OGTT
Main finding
As reported in the abstract
Correlation of disposition index (DI) with blood glucose in IGT (weak), r
0.04
95% CI −0.63 to 0.44
Further findings
Correlation of DI/cle estimated from simpler tests with DI/cle from 2 clamp tests
- Hyperinsulinemic-euglycemic clamp, r
- 0.52 (95% CI 0.37 to 0.64)
- OGTT, r
- 0.43 (95% CI 0.24 to 0.58)
- Fasting blood test, r
- 0.54 (95% CI 0.38 to 0.68)
- Significantly correlated
Original publication
DI/cle, a Measure Consisting of Insulin Sensitivity, Secretion, and Clearance, Captures Diabetic States. J Clin Endocrinol Metab. Published 5 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →