A Mathematical Model-Derived Disposition Index Without Insulin Validated in Youth With Obesity
Authors' conclusion
mDI-woI is better than oDI or the labor-intensive cDI for detecting dysglycemia in obese youth. Bypassing insulin measurements with mDI-woI from the OGTT provides a cost-effective approach for large-scale epidemiological studies of dysglycemia in youth.
Study context
- Population
- Youth with obesity: 68 NGT, 33 IGT, 29 T2D; 5-point and 3-point oral glucose tolerance tests (OGTTs) synchronized with hyperinsulinemic-euglycemic and hyperglycemic clamps
- Participants
- 130 participants
- Comparison
- Model-derived DI with insulin (mDI) and without insulin (mDI-woI) vs clamp DI (cDI) and oral DI (oral disposition index (oDI))
Methodological detailsvalidation study
- Validation study
Primary result
As reported in the abstract
Detection of IGT (ROC analysis)
- Model-derived DI correlated well with clamp DI (R, logged)
- 0.76
- AUC for detecting IGT, mDI and mDI-woI
- 0.88-0.87
- AUC for detecting IGT, oDI and cDI
- 0.68-0.65
- AUC for detecting IGT, mean glucose
- 0.87
- Decrease between NGT and IGT, mDI and mDI-woI
- 60% and 59%
- Decrease between NGT and IGT, oDI and cDI
- 29% and 27%
Original publication
A Mathematical Model-Derived Disposition Index Without Insulin Validated in Youth With Obesity. J Clin Endocrinol Metab. Published 22 August 2024. doi:10.
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