Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study
Authors' conclusion
A revised definition of diabetes overtreatment is needed to better manage older insulin-treated patients and protect them from hypoglycemia.
Study context
- Population
- Patients aged ≥75 years with insulin-treated T2D from the HYPOAGE cohort, using continuous glycemic monitoring (CGM) for 28 days; 81.6 ± 5.4 years, 59% male
- Participants
- 134 patients
- Comparison
- Fixed vs individualized proxy definitions of diabetes overtreatment for predicting hypoglycemia
- Outcome
- TBR ≥1%
Methodological detailscohort (HYPOAGE)
- Cohort (HYPOAGE)
Performance
As reported in the abstract
Prediction of hypoglycemia (TBR ≥1%) by overtreatment proxy definitions · 28 days CGM
- Both proxy definitions had low sensitivity and accuracy in predicting hypoglycemia
- CGM showed time below range (TBR) >1% in nearly all patients regardless of overtreatment status
Further findings
Overtreated patients
Original publication
Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study. Diabetes Care. Published 22 August 2024. doi:10.
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