Increased Early Postprandial Glucagon Concentrations in Humans With Newly Diagnosed Type 2 Diabetes and Steatotic Liver Disease
Authors' conclusion
Hyperglucagonemia in the face of higher HLC in early T2D is not due to differences in insulin sensitivity or glucagonotropic metabolites but could suggest hepatic glucagon resistance.
Study context
- Population
- Individuals with newly diagnosed T2D and matched individuals with normal glucose tolerance (NGT); mixed-meal tolerance tests, hyperinsulinemic-euglycemic clamps, indirect calorimetry, 1H/31P MR spectroscopy and MRI
- Participants
- 50 vs 50
- Exposure
- Newly diagnosed T2D vs normal glucose tolerance
- T2Dn = 50
- NGTn = 50reference
- Outcome
- HLC and fasting and postprandial glucagonemia
Methodological detailsage-, sex- and BMI-matched
- Age-, sex- and BMI-matched
Main finding
As reported in the abstract
Higher hepatic lipid content (HLC) with T2D vs NGT
∼65%
Higher fasting glucagonemia with T2D vs NGT
∼30%
Higher postprandial glucagonemia with T2D vs NGT
∼75%
Postprandial glucagon related to HLC only in T2D; higher early postprandial glucagonemia with combined MASLD and T2D
∼47%
Observational data: associations, not effects.
Original publication
Increased Early Postprandial Glucagon Concentrations in Humans With Newly Diagnosed Type 2 Diabetes and Steatotic Liver Disease. Diabetes Care. Published 2 April 2026. doi:10.
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