A ketone monoester drink reduces postprandial blood glucose concentrations in adults with type 2 diabetes: a randomised controlled trial
Authors' conclusion
KME ingestion appears to delay glucose absorption in adults with type 2 diabetes, thereby reducing postprandial glucose concentrations. Future work to explore the therapeutic potential of KME supplementation in type 2 diabetes is warranted.
Study context
- Population
- Adults with T2D (age 59±1.7 years, 50% female, BMI 32±1 kg/m², HbA1c 54±2 mmol/mol [7.1±0.2%]), University of Exeter, UKall 10 analysed
- Participants
- 10 adults
- Comparison
- Pre-meal ketone monoester (KME) vs taste-matched non-caloric placebo before a mixed-meal tolerance test
- Primary endpoint
- Endogenous glucose production
Methodological detailsdouble-blind, placebo-controlled, crossover, single-centre
- Double-blind
- Placebo-controlled
- Crossover
- Single-centre
Primary result
As reported in the abstract
Postprandial endogenous glucose production
Secondary outcomes
Plasma β-OHB with KME
- Plasma β-OHB increased with KME from 0.3±0.03 mmol/l to a peak of 4.3±1.2 mmol/l (mean ± SEM)
- 0.3±0.03 to 4.3±1.2 mmol/l
Postprandial glucose with KME · 2 h and 4 h
- Reduction in 2 h postprandial glucose with KME
- ≈18%
- Reduction in 4 h postprandial glucose with KME
- ≈12%
- Decrease in 2 h rate of glucose appearance after meal with KME
- 28%
- All p<0.05
Plasma NEFA and insulin
- Lower blood glucose associated with suppressed plasma NEFA after KME
- No difference in plasma insulin between control and KME
Safety
- No adverse effects of KME ingestion observed
Original publication
A ketone monoester drink reduces postprandial blood glucose concentrations in adults with type 2 diabetes: a randomised controlled trial. Diabetologia. Published 14 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →