Pre-Meal Whey Protein Alters Postprandial Insulinemia by Enhancing β-Cell Function and Reducing Insulin Clearance in T2D
Authors' conclusion
In adults with T2D, pre-meal WP reduced PPG by coordinating an enhancement in β-cell function with a reduction in insulin clearance. This enabled an efficient postprandial insulinemic profile to be achieved without requiring further β-cell stimulation.
Study context
- Population
- Adults with T2D (HbA1c 56.7 ± 8.8 mmol/mol) undergoing 2,240-minute mixed-meal tolerance testscrossover
- Participants
- 18 adults
- Comparison
- Pre-meal whey protein vs placebo
- Primary endpoint
- Change in PPG incremental area under the curve (iAUC; prespecified)
Methodological detailssingle-blind, placebo-controlled
- Single-blind
- Placebo-controlled
Primary result
As reported in the abstract
PPG incremental area under the curve (iAUC) reduced by whey protein (WP) (P < .05)
−16%
Peak PPG change reduced by WP (P < .05)
−1.5 mmol/L
Further findings
β-cell function
- Greater after WP vs placebo (P = .001)
- 40%
Postprandial insulin clearance
- Reduction with WP vs placebo (P < .0001)
- −22%
- Post hoc
Glucagon and GLP-1 iAUC
- Increase with WP (both P < .0001)
- 5.9-fold
Insulin iAUC
- Increase with WP (P < .001)
- 1.5-fold
Insulin secretion rate (insulin secretion rates (ISR))
- ISR unaffected by WP (P = .133)
Original publication
Pre-Meal Whey Protein Alters Postprandial Insulinemia by Enhancing β-Cell Function and Reducing Insulin Clearance in T2D. J Clin Endocrinol Metab. Published 3 February 2023. doi:10.
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