Elevations in plasma glucagon are associated with reduced insulin clearance after ingestion of a mixed-macronutrient meal in people with and without type 2 diabetes
Authors' conclusion
The ingestion of a mixed-macronutrient meal augments differing temporal profiles in insulin clearance among individuals without type 2 diabetes, which is associated with HOMA-IR and the secretion of glucagon. Further research investigating the role of hepatic glucagon signalling in postprandial insulin kinetics is warranted.
Study context
- Population
- Lean and centrally obese normoglycaemic individuals and people with T2D after a standardised cereal-and-milk breakfast meal
- Participants
- 12 / 11 / 19
- Comparison
- Lean-NGT vs Obese-NGT vs T2D
- Lean-NGTn = 12reference
- Obese-NGTn = 11
- T2Dn = 19
- Primary endpoint
- Temporal responses of insulin clearance after a standardised breakfast meal
Methodological detailsPre-hepatic insulin secretion by C-peptide deconvolution; insulin clearance by single-pool model; insulin sensitivity by oral minimal model
- Pre-hepatic insulin secretion by C-peptide deconvolution; insulin clearance by single-pool model; insulin sensitivity by oral minimal model
Primary result
As reported in the abstract
Mean AUC for insulin clearance during the test
Obese-NGT vs Lean-NGT: P < 0.01 · T2D vs Lean-NGT: P < 0.01
Further findings
Predictors of insulin clearance AUC
- HOMA-IR and glucagon AUC predicted insulin clearance AUC, independent of BMI, age or insulin sensitivity (adjusted R2)
- 0.670
- Increased glucagon AUC: reduction in insulin clearance AUC of 40% (≈−0.75 l min-1 m-2)
- P < 0.001
Original publication
Elevations in plasma glucagon are associated with reduced insulin clearance after ingestion of a mixed-macronutrient meal in people with and without type 2 diabetes. Diabetologia. Published 13 August 2024. doi:10.
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