Efficacy and safety of switching to iGlarLixi from premixed insulin therapy in patients with type 2 diabetes: A real‐world experience
Authors' conclusion
Switching from premixed insulin to iGlarLixi is a safe and effective strategy to simplify therapy and improve glycaemic management. Insulin resistance may influence response.
Study context
- Population
- Adults with T2D who transitioned from premixed insulin to iGlarLixi, July 2020–July 2023, Taipei Veterans General Hospital; mean age 67.6 ± 10.5 years
- Participants
- 40 adults
- Exposure
- Switch from premixed insulin to iGlarLixi
- iGlarLixin = 40
- Outcome
- HbA1c change in patients with baseline HbA1c >58 mmol/mol (7.5%)
- Follow-up
- 6 months
Methodological detailssingle-centre, real-world
- Single-centre
- Real-world
Main finding
As reported in the abstract
HbA1c, patients with baseline HbA1c >58 mmol/mol (7.5%, n = 28)
HbA1c decreased from baseline to 6 months
from 79 ± 18 (9.4% ± 1.7%) to 67 ± 18 mmol/mol (8.2% ± 1.6%)
p = 0.01
Achieved HbA1c ≤53 mmol/mol (7.0%)
23.1%
Observational data: associations, not effects.
Further findings
HbA1c, patients previously on 40-50 units/day of premix insulin (largest reduction)
- HbA1c decreased
- from 83 ± 21 [9.8% ± 1.9%] to 65 ± 15 mmol/mol [8.1% ± 1.4%], p = 0.037
Total insulin dose and injection frequency
- Total insulin dose and injection frequency significantly decreased
- P < 0.001
Patients with pre-existing hypoglycaemia
- Glycaemic control remained stable despite reductions in insulin dose and injection frequency
- P = 0.001, p = 0.032, respectively
Predictors of suboptimal glycaemic response
- Higher HOMA-IR significantly associated with suboptimal glycaemic response in multivariate model
- P = 0.037
Safety
- Hypoglycaemia incidence dropped
- from 60.0% to 12.5% (p < 0.001)
Original publication
Efficacy and safety of switching to iGlarLixi from premixed insulin therapy in patients with type 2 diabetes: A real‐world experience. Diabet Med. Published 1 April 2026. doi:10.
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