Surrogate measures of first-phase insulin secretion versus reference methods intravenous glucose tolerance test and hyperglycemic clamp: a systematic review and meta-analyses
Authors' conclusion
Surrogate measures from the first 30 min of an OGTT capture the first phase of insulin secretion and are a good choice for epidemiological studies. HOMA-beta has a moderate correlation to the reference methods but is not a measure of the first phase specifically.
Study context
- Population
- Adults with normal glucose tolerance, pre-diabetes or T2D in whom first-phase insulin secretion was measured by hyperglycemic clamp (HGC) or intravenous glucose tolerance test (IVGTT) and ≥1 surrogate measure33 articles
- Participants
- 5,362 adults
- Comparison
- Surrogate measures of first-phase insulin secretion vs reference methods
- Homeostatic model assessment (HOMA)-betan = 17
- IGI(30)n = 13
- Outcome
- Correlation between first-phase insulin secretion measured with gold standard and surrogate methods
Methodological detailsrandom-effects meta-analyses, QUADAS-2 quality assessment, Searches of PubMed, Cochrane Central and Web of Science to end of June 2021
- Random-effects meta-analyses
- QUADAS-2 quality assessment
- Searches of PubMed, Cochrane Central and Web of Science to end of June 2021
Pooled result
As reported in the abstract
Pooled correlation to the reference methods
HOMA-beta
0.48
pooled correlation · 95% CI 0.40–0.56
IGI(30)
0.61
pooled correlation · 95% CI 0.54–0.68
Kadowaki
0.67
correlation · 95% CI 0.61–0.73
Stumvoll's first-phase secretion
0.65
correlation · 95% CI 0.58–0.71
Original publication
Surrogate measures of first-phase insulin secretion versus reference methods intravenous glucose tolerance test and hyperglycemic clamp: a systematic review and meta-analyses. BMJ Open Diabetes Res Care. Published 16 July 2024. doi:10.
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