Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes
Authors' conclusion
This outcome contrasts with the oxytocin-induced attenuation of early postprandial glucose excursions in normal-weight individuals, but is in line with the absence of respective effects in men with obesity. We conclude that insulin resistance in type 2 diabetes is associated with decreased sensitivity to the acute glucoregulatory effect of oxytocin in male individuals.
Study context
- Population
- Fasted men with non-insulin-treated T2D; age 63.40 ± 1.36 years, BMI 27.77 ± 0.66 kg/m², HbA1c 6.86% ± 0.08%, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) 3.44 ± 0.39 (mean ± SE)crossover
- Participants
- 25 men
- Comparison
- Intranasal oxytocin vs placebo before OGTT
- Primary endpoint
- Acute glucoregulatory impact: glucose metabolism after OGTT (AUC glucose, insulin, C-peptide)
- Follow-up
- 3 hours after OGTT onset
Methodological detailsdouble-blind, Key outcomes compared with previous results in men with normal weight or obesity
- Double-blind
- Key outcomes compared with previous results in men with normal weight or obesity
Primary result
As reported in the abstract
AUC glucose
Further findings
AUC insulin · 3 hours after OGTT onset
AUC C-peptide · 3 hours after OGTT onset
Plasma oxytocin and heart rate
- Oxytocin vs placebo increased plasma oxytocin concentrations and reduced heart rate
Original publication
Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes. Diabetes Obes Metab. Published 8 August 2024. doi:10.
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