Novel time-saving oral glucose tolerance test (OGTT) sparing HbA1c-HOMA2 based algorithm for the diagnosis of cystic fibrosis-related diabetes
Authors' conclusion
The composite index DIPIc is a suitable, less invasive screening method for CFRD, which enables to avoid many OGTTs.
Study context
- Population
- Patients with cystic fibrosis screened for cystic fibrosis-related diabetes (CFRD), single centreHOMA indices recovered
- Participants
- 72 patients
- Comparison
- HbA1c and HOMA2 indices vs OGTT as gold standard for CFRD screening
- Outcome
- CFRD screening accuracy vs OGTT (gold standard) and OGTT sparing with stepwise DIPIc algorithm
Methodological detailsretrospective, cross-sectional, single-centre
- Retrospective
- Cross-sectional
- Single-centre
Performance
As reported in the abstract
Sensitivity of CFRD exclusion cutoff less than −1.7445
98 %
Specificity of CFRD diagnostic threshold greater than 0.4543
98 %
OGTT sparing with exclusion cutoff and diagnostic threshold combined
71 %
Original publication
Novel time-saving OGTT sparing HbA1c-HOMA2 based algorithm for the diagnosis of cystic fibrosis-related diabetes. Diabetes Res Clin Pract. Published 2 February 2024. doi:10.
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