Cystic fibrosis‐related diabetes develops from a combination of insulin secretion defects and insulin resistance
Main finding · CFRD-free survival by quartiles of insulin resistance and by combined insulin secretion (insulinogenic index) and insulin resistance (Stumvoll)Result — go to the resultHR for progression to CFRD 11.2Authors' conclusion
Insulin resistance is correlated with glucose homeostasis and the risk of progression to CFRD. Patients combining low insulin secretion and high insulin resistance had the greatest odds of developing CFRD over a 15-year period.
Study context
- Population
- Individuals living with cystic fibrosis (CF) undergoing 2-h OGTT every 12–24 months until CFRD or end of follow-up (up to 15 years)
- Participants
- 303 individuals
- Exposure
- Quartiles of insulin resistance and combined insulin secretion/insulin resistance categories
- Outcome
- Progression to CFRD (CFRD-free survival)
- Follow-up
- Up to 15 years
Main finding
As reported in the abstract
CFRD-free survival by quartiles of insulin resistance and by combined insulin secretion (insulinogenic index) and insulin resistance (Stumvoll)
HR for progression to CFRD
11.2
P < 0.0001
- CFRD-free survival significantly different between quartiles of insulin resistance
- P < 0.0001
Observational data: associations, not effects.
Original publication
Cystic fibrosis‐related diabetes develops from a combination of insulin secretion defects and insulin resistance. Diabetes Obes Metab. Published 9 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →