Association between gastrectomy and the risk of type 2 diabetes in gastric cancer survivors: A nationwide cohort study
Authors' conclusion
These results show a significantly reduced risk of T2DM in gastric cancer patients undergoing subtotal gastrectomy and a significantly increased risk of T2DM in gastric cancer patients undergoing total gastrectomy, which is mitigated by continuous vitamin B12 supplementation.
Study context
- Population
- Gastric cancer patients aged >20 years who underwent gastrectomy 2008–2015, South Korean National Health Insurance Service database150,074 gastrectomy
- Exposure
- Total or subtotal gastrectomy vs matched controls without gastrectomy
- Matched controlsn = 301,508reference
- Outcome
- Incident T2D
- Follow-up
- Median 4.4 years after 2-year time lag
Methodological detailsnationwide, population-based, age- and sex-matched controls
- Nationwide
- Population-based
- Age- and sex-matched controls
Main finding
As reported in the abstract
median follow-up 4.4 years
Each group vs matched controlsAdjusted hazard ratio (95 % CI)
Total gastrectomy
1.34(1.23–1.47)
Subtotal gastrectomy
0.81(0.76–0.86)
- Developed T2D among 78,006 subjects
- 4,597 (5.9 %)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| T2D after total gastrectomy, no vitamin B12 supplementationTotal gastrectomy, no vitamin B12vs Matched controls | 1.60 (1.33–1.92) | |
| T2D after total gastrectomy, continuous vitamin B12 supplementationTotal gastrectomy, continuous vitamin B12vs Matched controlsClose to being statistically significant | 0.70 (0.49–1.01) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Association between gastrectomy and the risk of type 2 diabetes in gastric cancer survivors: A nationwide cohort study. Diabetes Metab. Published 9 August 2024. doi:10.
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