Triglyceride-glucose index predicts type 2 diabetes mellitus more effectively than oral glucose tolerance test-derived insulin sensitivity and secretion markers
Main finding · Incident T2DResult — go to the resultHazard ratio 2.36 CI 1.9–2.93Authors' conclusion
The TyG index is associated with HOMA-IR and composite ISI even with NGT. The TyG index demonstrated independent predictability for T2DM incidence in individuals with NGT, better than OGTT-derived insulin sensitivity and secretion markers.
Study context
- Population
- Korean adults with normal glucose tolerance, Korean Genome and Epidemiology Study
- Participants
- 6,072 adults
- Exposure
- Triglyceride-glucose (TyG) index quartiles (Q4 vs lowest); TyG index vs homeostasis model assessment of insulin resistance (HOMA-IR) and OGTT-derived insulin sensitivity and secretion markers for predicting T2D
- Outcome
- Incident T2D
- Follow-up
- 18-year follow-up
Methodological detailscommunity-based, 18-year follow-up
- Community-based
- 18-year follow-up
Main finding
As reported in the abstract
Hazard ratio
2.36
CI 1.9–2.93
Q4
HR 2.36 (CI 1.9–2.93)
- Developed T2D
- 999 individuals
- AUC of TyG index, highest among HOMA-IR and OGTT-derived insulin sensitivity and secretion markers
- 0.642
Observational data: associations, not effects.
Further findings
Baseline correlation of TyG index with HOMA-IR and composite insulin sensitivity index (ISI)
- TyG vs HOMA-IR, β
- 0.045 (p < 0.001)
- TyG vs composite ISI, β
- −0.105 (p < 0.001)
Original publication
Triglyceride-glucose index predicts type 2 diabetes mellitus more effectively than oral glucose tolerance test-derived insulin sensitivity and secretion markers. Diabetes Res Clin Pract. Published 26 March 2024. doi:10.
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