Associations of Regional Body Fat With Risk of Cardiovascular Disease and Mortality Among Individuals With Type 2 Diabetes
Authors' conclusion
Among people with T2D, arm fat and trunk fat were positively, whereas leg fat was inversely, associated with the risk of CVD and mortality. These findings highlight the importance of considering both the amount and the location of body fat when assessing CVD and mortality risk among individuals with T2D.
Study context
- Population
- Participants with T2D from the UK Biobank; regional body fat measured by bioelectric impedancemain analysis
- Participants
- 21,472 participants
- Exposure
- Extreme quartiles of regional body fat percentage
- Outcome
- CVD
- Follow-up
- Median 7.7 years
Methodological detailsUK Biobank, multivariable-adjusted Cox proportional-hazards regression
- UK Biobank
- Multivariable-adjusted Cox proportional-hazards regression
Main finding
As reported in the abstract
- Multivariable-adjusted HR of cardiovascular disease (CVD), extreme quartiles, leg fat %
- 0.72 (95% CI 0.58-0.90)
- Multivariable-adjusted HR of CVD, extreme quartiles, arm fat %
- 1.63 (95% CI 1.29-2.05)
- Multivariable-adjusted HR of CVD, extreme quartiles, trunk fat %
- 1.27 (95% CI 1.06-1.52)
- Higher arm fat % linearly associated with increased CVD risk
- Pnonlinear > .05
- Higher trunk fat % nonlinearly associated with increased CVD risk
- Pnonlinear < .05
- Higher leg fat % nonlinearly associated with lower CVD risk
- Pnonlinear < .05
- CVD events
- 3976
Observational data: associations, not effects.
Further findings
All-cause and CVD mortality
- Similar patterns of associations as for CVD
Independence from traditional obesity measures
- Leg fat %, but not other regional fat %, associated with CVD risk independently of traditional measures of obesity
Original publication
Associations of Regional Body Fat With Risk of Cardiovascular Disease and Mortality Among Individuals With Type 2 Diabetes. J Clin Endocrinol Metab. Published 26 March 2024. doi:10.
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