Metabolomic signatures of hepatic steatosis reveal heterogeneity in cardiometabolic risk and responses to lifestyle interventions in type 2 diabetes: a post hoc analysis
Authors' conclusion
Among individuals with T2D, a metabolomics-based liver fat score, particularly the discordance between metabolomic and imaging assessments, identifies systemic metabolic heterogeneity and differential responsiveness to lifestyle interventions. Future research is warranted to evaluate its performance in improving risk stratification and personalizing lifestyle intervention.
Study context
- Population
- Adults with T2D and overweight/obesity in a three-arm lifestyle intervention RCT
- Comparison
- Low Δliver fat vs high Δliver fat
Methodological detailspost hoc analysis, three-arm lifestyle intervention
- Post hoc analysis
- Three-arm lifestyle intervention
Primary result
As reported in the abstract
Associations of mliver fat and Δliver fat with cardiometabolic traits and intervention response
- Both mliver fat and Δliver fat associated with body composition, glucose indices, insulin sensitivity and TG; only Δliver fat independent of MRI-measured liver fat
- Despite comparable MRI-measured liver fat, low Δliver fat had a more favorable cardiometabolic profile vs high Δliver fat
- Low Δliver fat derived greater and more sustained benefits from diet intervention, with more pronounced long-term improvements in weight, insulin sensitivity and β-cell function
- Post hoc analysis
Original publication
Metabolomic signatures of hepatic steatosis reveal heterogeneity in cardiometabolic risk and responses to lifestyle interventions in type 2 diabetes: a post hoc analysis. Cardiovasc Diabetol. Published 29 April 2026. doi:10.
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