Evaluation of Family History of Diabetes and the Development of Cystic Fibrosis-Related Diabetes in a Clinical Cystic Fibrosis Cohort
Authors' conclusion
Type 2 diabetes and CFRD family history double CFRD risk. PI quadruples CFRD odds. Each age decade increased CFRD odds by 46%, but sex, genotype category, and BMI were not associated.
Study context
- Population
- Modulator-treated cystic fibrosis cohort, single centre
- Exposure
- Diabetes family history vs none
- Outcome
- CFRD
Methodological detailssingle-centre, clinician-collected family history, modified Poisson regression with robust SE, adjusted for age, sex, genotype category, pancreatic insufficiency (PI) and body mass index (BMI) category
- Single-centre
- Clinician-collected family history
- Modified Poisson regression with robust SE
- Adjusted for age, sex, genotype category, PI and BMI category
Main finding
As reported in the abstract
CFRD risk by diabetes family history
Incidence rate ratio (CI)P value
T2D family history157% increased CFRD risk
2.57(1.53–4.32)
P < 0.001CFRD family history92% increase in CFRD risk
1.92(1.15–3.21)
P = 0.013Observational data: associations, not effects.
Further findings
Pancreatic insufficiency and CFRD
| OR (CI) | P value | ||
|---|---|---|---|
| PI | 3.99 (1.35–11.81) | P = 0.012 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Age (per additional decade) and CFRD46% increased CFRD odds | 1.46 (1.18–1.81) | P = 0.001 | |
| 0.512Odds ratio (log scale) |
Sex, genotype category and BMI
- Sex, genotype category, and BMI were not associated with CFRD
Original publication
Evaluation of Family History of Diabetes and the Development of Cystic Fibrosis-Related Diabetes in a Clinical Cystic Fibrosis Cohort. Endocr Pract. Published 29 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →