Dose–Response Associations of Intermittent Lifestyle Physical Activity Micropatterns and Incident Type 2 Diabetes
Authors' conclusion
Among adults who do not engage in leisure-time exercise, accruing brief, intermittent bouts of moderate- to vigorous-intensity physical activity during day-to-day routines may be a promising strategy for prevention of type 2 diabetes.
Study context
- Population
- UK Biobank accelerometry substudy participants reporting no leisure-time exercise and without T2D at baseline; mean age 62.3 years, 56.4% female665 developed T2D
- Participants
- 22,706 participants
- Exposure
- Daily duration and frequency of vigorous intermittent lifestyle physical activity (VILPA) and MV-ILPA vs none/lower
- Outcome
- Incident T2D (linked primary care, hospital and death records)
- Follow-up
- Average 7.9 years
Methodological detailsUK Biobank accelerometry substudy, wrist-worn accelerometers, multivariable-adjusted Fine-Gray subdistribution hazard models accounting for competing risks
- UK Biobank accelerometry substudy
- Wrist-worn accelerometers
- Multivariable-adjusted Fine-Gray subdistribution hazard models accounting for competing risks
Main finding
As reported in the abstract
Median VILPA 3.9 min/day vs no VILPA: lower risk of T2D
36%
Median MV-ILPA 25.3 min/day vs 3.9 min/day of MV-ILPA: lower risk of T2D
46%
Daily VILPA frequency: near-linear inverse association; 10.4 bouts/day (median) vs 0 bouts/day, HR
0.64 (0.51-0.81) (95% CI)
Daily MV-ILPA frequency: U-shaped pattern, risk reductions plateauing at ≈56 bouts/day, HR
0.54 (0.39-0.76) (95% CI)
Observational data: associations, not effects.
Original publication
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