Screening for Diabetes and Prediabetes in Cystic Fibrosis Using a Nonfasting 50-Gram 1-Hour Oral Glucose Challenge Test
Authors' conclusion
GCT offers a practical, in-clinic method for CFRD screening. This spares low-risk individuals from OGTT, while maintaining high sensitivity for CFRD.
Study context
- Population
- Participants with cystic fibrosis (CF) ≥10 years old, without known diabetes; Oral glucose tolerance test (OGTT) on a separate day; 94 normal glucose tolerance, 81 pre-CFRD, 10 CFRD
- Participants
- 185 participants
- Comparison
- Nonfasting 50-g 1-h glucose challenge test (GCT) vs RPG, RCG and hemoglobin A1C (HbA1c) for detecting pre-CFRD or CFRD, against OGTT
- Outcome
- Detection of pre-CFRD or CFRD (ROC-AUC); GCT cutoff with high sensitivity and reasonable specificity
Performance
As reported in the abstract
ROC-AUC for detecting pre-CFRD or CFRD
| Test or model | Value | AUC |
|---|---|---|
| GCTpl | 0.73 (95% CI 0.65–0.80) | 0.73 |
| RPG | 0.56 (CI 0.48–0.65) | 0.56 |
| RCG | 0.55 (CI 0.46 = 0.63) | 0.55 |
| HbA1c | 0.62 (CI 0.53–0.67) | 0.62 |
Value
GCTpl0.73 (95% CI 0.65–0.80)
RPG0.56 (CI 0.48–0.65)
RCG0.55 (CI 0.46 = 0.63)
HbA1c0.62 (CI 0.53–0.67)
AUC
GCTpl0.73
RPG0.56
RCG0.55
HbA1c0.62
- GCTpl vs RPG: P = 0.003 — higher with GCTpl
- GCTpl vs RCG: P = 0.002 — higher with GCTpl
- GCTpl vs HbA1c: P = 0.02 — higher with GCTpl
Further findings
| Outcome | GCTpl | RPG | HbA1c |
|---|---|---|---|
| ROC-AUC for detecting CFRD | |||
| AUC | 0.75 | 0.64 | 0.56 |
- GCTpl cutoff 147 mg/dL for detecting CFRD
- 90% · sensitivity · specificity 58%
- GCTpl cutoff 147 mg/dL for detecting CFRD — Could reduce OGTTs needed by
- 56%
Original publication
Screening for Diabetes and Prediabetes in Cystic Fibrosis Using a Nonfasting 50-Gram 1-Hour Oral Glucose Challenge Test. Diabetes Care. Published 30 March 2026. doi:10.
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