Feasibility, Acceptability, and Validity of Home Continuous Glucose Monitoring–Based Oral Glucose Tolerance Test in Youth
Authors' conclusion
Home-OGTT was acceptable, but strategies to precisely capture glucose ingestion timing could improve feasibility. Alternate dysglycemia thresholds may need to be defined prior to using CGM as a method for T2D screening in youth.
Study context
- Population
- Youth aged 8 to 18 years with overweight/obesity and prediabetes-range hemoglobin A1c (HbA1c), fasting glucose or 2-hour glucose on oral glucose tolerance test (OGTT), and/or ≥1 guideline-based T2D risk factors; pediatric clinical and translational research center30 with valid home-OGTT data
- Participants
- 39 participants
- Exposure
- Home continuous glucose monitoring (CGM)-based OGTT vs research-center serum OGTT
- Outcome
- Feasibility (% with valid home-OGTT data), acceptability (survey and interview responses) and validity (sensitivity, specificity, PPV, NPV of home- vs research-OGTT dysglycemia: fasting ≥100 mg/dL; 2-hour ≥140 mg/dL)
Methodological detailssingle-centre, blinded CGM
- Single-centre
- Blinded CGM
Main finding
As reported in the abstract
Feasibility, acceptability and validity of home-OGTT
| Group | Specificity, fasting | Specificity, 2-hour | PPV, fasting | PPV, 2-hour | Sensitivity and NPV |
|---|---|---|---|---|---|
| Home-OGTT | 10% | 25% | 3.6% | 18.2% | ≥80% |
Home-OGTT
Specificity, fasting10%
Specificity, 2-hour25%
PPV, fasting3.6%
PPV, 2-hour18.2%
Sensitivity and NPV≥80%
- Valid home-OGTT data (feasibility)
- 30 (77%)
- Acceptability excellent/great
- 92%
- Acceptability neutral
- 8%
Observational data: associations, not effects.
Original publication
Feasibility, Acceptability, and Validity of Home Continuous Glucose Monitoring–Based Oral Glucose Tolerance Test in Youth. J Clin Endocrinol Metab. Published 6 December 2024. doi:10.
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