The effect of glucagon‐like peptide‐1 receptor agonists on cardiac function and structure in patients with or without type 2 diabetes mellitus: An updated systematic review and meta‐analysis
Pooled result · E/e' ratioResult — go to the resultMD −0.73 95% CI −1.34 to −0.13Authors' conclusion
In this systematic review and meta-analysis, GLP-1RAs were found to have a positive impact on left ventricle diastolic function, hypertrophy, and exercise capacity, but had no effect on systolic function.
Study context
- Population
- People with or without T2D; PubMed, Embase and ClinicalTrials.gov
- Participants
- 898 people15 trials
- Comparison
- GLP-1 RA vs control
- Outcome
- Change in mitral inflow E-velocity to tissue Doppler e' velocity (E/e') ratio
Methodological detailsupdated
- Updated
Pooled result
E/e' ratio
MD
−0.73
95% CI −1.34 to −0.13
GLP-1 RAvs control
MD −0.73 (95% CI −1.34 to −0.13)
As reported in the abstract
Further pooled results
Left ventricular mass (LVM)
| MD (g) (95% CI) | ||
|---|---|---|
| GLP-1RAs | −3.86 (−7.60 to −0.12) | |
| −10−505Difference, g (linear scale) |
Left atrial volume
| MD (mL) (95% CI) | ||
|---|---|---|
| GLP-1RAs | −8.20 (−12.37 to −4.04) | |
| −15−10−505Difference, mL (linear scale) |
NT-proBNP level
| SMD (95% CI) | ||
|---|---|---|
| GLP-1RAs | −0.27 (−0.47 to −0.06) | |
| −0.6−0.4−0.200.2Difference (linear scale) |
| Outcome | Estimate |
|---|---|
| 6-min walk test | MD +22.31 m (95% CI 1.64–42.99) |
| LVEFNo effect | MD +0.31 % (95% CI −1.02 to 1.64) |
Original publication
The effect of glucagon‐like peptide‐1 receptor agonists on cardiac function and structure in patients with or without type 2 diabetes mellitus: An updated systematic review and meta‐analysis. Diabetes Obes Metab. Published 26 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →