Age‐ and gender‐adjusted estimated glomerular filtration rate definition reveals hyperfiltration as a risk factor for renal function deterioration in type 2 diabetes
Main finding · Rapid DKD progressionResult — go to the resultHazard ratio 1.66 95% CI 1.41–1.95Authors' conclusion
In addition to using the current Kidney Disease: Improving Global Outcomes CGA classification system, considering glomerular hyperfiltration status can improve the accuracy of predicting DKD progression.
Study context
- Population
- T2D patients with initial estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73m2; 7.2% had hyperfiltration
- Participants
- 7,563 patients
- Exposure
- Hyperfiltration vs normofiltration
- Outcome
- Rapid DKD progression (eGFR decline >5 mL/min/1.73m2/year)
- Follow-up
- Mean 4.65 ± 3.86 years
Methodological detailsobservational, linear mixed effect model, Cox regression with time-varying covariate model
- Observational
- Linear mixed effect model
- Cox regression with time-varying covariate model
Main finding
Rapid DKD progression
Hazard ratio
1.66
95% CI 1.41–1.95
P < 0.001
By group
Hyperfiltrationvs Normofiltration
HR 1.66 (95% CI 1.41–1.95); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Hyperfiltration | Normofiltration | P value |
|---|---|---|---|
| Rate of eGFR declineHigher rate of decline with hyperfiltration | −2.0 ± 0.9 mL/min/1.73m2/year | −1.1 ± 0.9 mL/min/1.73m2/year | P < 0.001 |
Rapid diabetic kidney disease (DKD) progression: hyperfiltration combined with albuminuria
- Risk of progression further compounded, HR range (all P < .001)
- 1.76-3.11
Original publication
Age‐ and gender‐adjusted estimated glomerular filtration rate definition reveals hyperfiltration as a risk factor for renal function deterioration in type 2 diabetes. Diabetes Obes Metab. Published 1 February 2024. doi:10.
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