Branched‐chain amino acid levels are inversely associated with incident and prevalent chronic kidney disease in people with type 2 diabetes
Authors' conclusion
Our study shows the intricate relationship between plasma BCAA levels and CKD in individuals with type 2 diabetes. While an association exists, its manifestation varies based on disease status and BMI, with no definitive evidence supporting a causal link between BCAAs and prevalent CKD.
Study context
- Population
- Individuals with T2D, Hoorn Diabetes Care System cohort, northwest Netherlands
- Exposure
- Baseline plasma levels of 172 metabolites, incl. Branched-chain amino acids (BCAAs), and incident and prevalent chronic kidney disease (CKD)
- Outcome
- Association of plasma metabolites with incident and prevalent CKD (logistic regression)
Methodological detailsreplication in UK Biobank, body mass index (BMI) mediation analysis, Mendelian randomization
- Replication in UK Biobank
- BMI mediation analysis
- Mendelian randomization
Main finding
As reported in the abstract
Incident CKD analysis: Ntotal/Ncase
462/81
Prevalent CKD analysis: Ntotal/Ncase
1247/120
Observational data: associations, not effects.
Further findings
Replication in UK Biobank
- Observed inverse effects replicated in UK Biobank
Causality (Mendelian randomization)
- No evidence for a causal relationship between BCAAs and prevalent CKD
Original publication
Branched‐chain amino acid levels are inversely associated with incident and prevalent chronic kidney disease in people with type 2 diabetes. Diabetes Obes Metab. Published 1 February 2024. doi:10.
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