Branched‐chain amino acids and type 2 diabetes: a bidirectional Mendelian randomization analysis
Authors' conclusion
These data suggest that the BCAAs are not mediators of T2D risk but are biomarkers of diabetes.
Study context
- Population
- Large genetic data sets for branched-chain amino acids (BCAAs) and T2D
- Comparison
- Genetically predicted BCAAs and T2D, in both directions
- Outcome
- Association of BCAA instrumental variables with T2D, and reverse association of T2D instrumental variables with each BCAA
Methodological detailstwo-sample, inverse-variance weighted, sensitivity analyses
- Two-sample
- Inverse-variance weighted
- Sensitivity analyses
Main finding
As reported in the abstract
BCAA IVs → T2D (excluding outliers)
Valine → T2D, β change in log-odds per SD change in valine
0.14
95% CI −0.06 to 0.33p = 0.17
Leucine → T2D, β
0.15
95% CI −0.02 to 0.32p = 0.09
Isoleucine → T2D, β
0.13
95% CI −0.08 to 0.34p = 0.24
Further findings
Reverse: T2D instrumental variables (IVs) → each BCAA
- T2D → valine, β per SD change in levels per log-odds change in T2D
- 0.08 (95% CI 0.05 to 0.10; p = 1.8 × 10-9)
- T2D → leucine, β
- 0.06 (95% CI 0.04 to 0.09; p = 4.5 × 10-8)
- T2D → isoleucine, β
- 0.06 (95% CI 0.04 to 0.08; p = 2.8 × 10-8)
Original publication
Branched‐chain amino acids and type 2 diabetes: a bidirectional Mendelian randomization analysis. Obesity (Silver Spring). Published 25 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →