Impact of age on the predictive value of NT-proBNP in patients with diabetes mellitus stabilised after an acute coronary syndrome
Authors' conclusion
Among patients with T2DM stabilised after an ACS, NT-proBNP level predicts death irrespective of age.
Study context
- Population
- Patients with T2D and recent Acute Coronary Syndrome (ACS) (stabilised), without HF, in the AleCardio trial of aleglitazar vs placebo; median age 61y (IQR 54, 67)
- Participants
- 7,226 patients
- Comparison
- NT-proBNP quartiles across age quartiles
- Primary endpoint
- All-cause and cardiovascular death
- Follow-up
- Median 104 weeks
Methodological detailsmultivariable Cox regression, central NT-proBNP measurement
- Multivariable Cox regression
- Central NT-proBNP measurement
Primary result
As reported in the abstract
NT-proBNP Q4 vs NT-proBNP Q1Adjusted hazard ratio (95 % CI)P value
All-cause death
6.9(4.0–12)
P < 0.001CV death
11(5.4–23)
P < 0.001- Within each age Q, baseline NT-proBNP in those who died vs survivors
- 3 times higher (all p < 0.001)
- Age × NT-proBNP interaction (continuous variables)
- nonsignificant
Further findings
Median NT-proBNP by age quartile (Q1 to Q4) · baseline
- Median NT-proBNP, age Q1, Q2, Q3, Q4
- 264, 318, 391, and 588 pg/ml
Relative prognostic information of NT-proBNP (percent of total X2), age Q1 to Q4
- Mortality
- 38 % to 75 %
- CV death
- 50 % to 88 %
Original publication
Impact of age on the predictive value of NT-proBNP in patients with diabetes mellitus stabilised after an acute coronary syndrome. Diabetes Res Clin Pract. Published 24 January 2024. doi:10.
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