QRS-T angle: is it a specific parameter associated with sudden cardiac death in type 2 diabetes? Results from the SURDIAGENE and the Mini-Finland prospective cohorts
Authors' conclusion
QRS-T angle was specifically associated with SCD risk and not with other causes of death, opening an avenue for refining SCD risk stratification in individuals with type 2 diabetes.
Study context
- Population
- Individuals with T2D, SURDIAGENE French prospective cohort (mean age 65 years; HbA1c 62±17 mmol/mol [7.8±1.5%]; 58% male); external validation in Mini-Finland participants with diabetesSURDIAGENE
- Participants
- 1,362 individuals
- Exposure
- Frontal QRS-T angle ≥90° vs <90° and other ECG/clinical parameters for sudden cardiac death (SCD) risk
- Outcome
- Sudden cardiac death (SCD), considering competing risk of non-SCD death
- Follow-up
- Median 7.4 years
Methodological detailscompeting risk models, external validation in Mini-Finland cohort
- Competing risk models
- External validation in Mini-Finland cohort
Main finding
As reported in the abstract
SCD (adjusted)
Subdistribution hazard ratio (95% CI)P value
Frontal QRS-T angle ≥90°
1.68(1.04–2.69)
P = 0.032NT-proBNP (per 1 log)per 1 log
1.26(1.06–1.50)
P = 0.009Per 1 log, as printed
- Deaths
- 494
- SCDs
- 94
Observational data: associations, not effects.
Further findings
Non-SCD causes of death
| sHR (95% CI) | P value | ||
|---|---|---|---|
| Frontal QRS-T angle | 1.08 (0.84–1.39) | P = 0.553 | |
| 0.512Subdistribution hazard ratio (log scale) |
SCD, Mini-Finland participants with diabetes (external validation)
| sHR (95% CI) | P value | ||
|---|---|---|---|
| QRS-T angle | 2.22 (1.05–4.71) | P = 0.04 | |
| 0.20.5125Subdistribution hazard ratio (log scale) |
Non-SCD causes of death
- QRS-T angle was the only marker not associated with non-SCD causes of death
SCD, Mini-Finland participants with diabetes (external validation)
- No association with other causes of death
Original publication
QRS-T angle: is it a specific parameter associated with sudden cardiac death in type 2 diabetes? Results from the SURDIAGENE and the Mini-Finland prospective cohorts. Diabetologia. Published 24 January 2024. doi:10.
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