Association of the triglyceride glucose index with sudden cardiac death in the patients with diabetic foot ulcer
Main finding · SCDResult — go to the resultHazard ratio 75.98 95 % CI 9.16 ∼ 630.40Authors' conclusion
Elevated TyG index independently confers an increased risk for SCD in individuals with DFU.
Study context
- Population
- T2D inpatients with diabetic foot ulcer (DFU), January 2010 to December 2023
- Participants
- 688 inpatients71 matched pairs
- Exposure
- Higher vs lower TyG index
- Outcome
- Sudden cardiac death (SCD)
- Follow-up
- Median 61 months
Methodological details1:1 propensity score matching
- 1:1 propensity score matching
Main finding
SCD
Hazard ratio
75.98
95 % CI 9.16 ∼ 630.40
P < 0.001
Highervs lower TyG index
HR 75.98 (95 % CI 9.16 ∼ 630.40); P < 0.001
As reported in the abstract
- Sudden cardiac death (SCD) cases recorded
- 38
Observational data: associations, not effects.
Further findings
Dose-response (Restricted cubic spline (RCS))
- SCD risk non-linearly correlated with gradual increases in TyG index
Subgroup analyses
- Consistent relationship between increasing TyG index and SCD risk across all subgroups
Original publication
Association of the triglyceride glucose index with sudden cardiac death in the patients with diabetic foot ulcer. Diabetes Res Clin Pract. Published 28 March 2025. doi:10.
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