Incidence of death and amputation in patients with a first diabetic foot ulcer: results from the CODIA cohort
Authors' conclusion
- Cumulative incidences of all-cause mortality and LLA during the months following hospitalization with a first diabetic foot ulcer were alarmingly high. Mortality risk was primarily associated with patient comorbidities, while amputation risk was closely associated with systemic inflammation and history of peripheral artery disease.
Study context
- Population
- Patients hospitalized with a first DFU, Greater Paris Hospitals, 08/2017 to 10/2023; median age 70.66 years, 67.64% males
- Participants
- 3,102 patients
- Outcome
- Cumulative incidence of death
- Follow-up
- 12 months
Methodological detailsclinical data warehouse, Greater Paris Hospitals, Kaplan-Meier and Aalen-Johansen estimators; multivariate Cox regression and Fine and Gray models
- Clinical data warehouse
- Greater Paris Hospitals
- Kaplan-Meier and Aalen-Johansen estimators; multivariate Cox regression and Fine and Gray models
Main finding
As reported in the abstract
Cumulative incidence of death at 12 months
21.64%
95%CI 20.11;23.26
Observational data: associations, not effects.
Further findings
Cumulative incidence of lower limb amputation (LLA) · 12 months
- Cumulative incidence of LLA at 12 months (22.54;25.79)
- 24.15%
- Death as a competing event
Risk factors for mortality
- Mortality risk associated with older age, chronic cardiac, hepatic or renal diseases, cancer history and systemic inflammation; overweight linked to lower mortality
Risk factors for LLA
- LLA risk factors: male sex, history of peripheral artery disease, emergency admission, systemic inflammation markers; dementia associated with lower risk
Original publication
Incidence of death and amputation in patients with a first diabetic foot ulcer: results from the CODIA cohort. Diabetes Metab. Published 5 September 2025. doi:10.
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