Nocturnal hypoxemic burden is associated with worsening prognosis of chronic kidney disease in patients with type 2 diabetes
Main finding · Incident very-high-risk CKDResult — go to the resultOdds ratio 2.96 95% CI 1.24–7.07Authors' conclusion
We identified NHB as a novel risk factor for worsening CKD prognosis in patients with T2D. Further research is needed to ascertain whether T90 reduction constitutes a clinically meaningful prevention target.
Study context
- Population
- Patients with T2D in the DIACORE sleep-disordered breathing sub-study with overnight oximetry; 41% female, mean age 65 years, median diabetes duration 9.0 years, median estimated glomerular filtration rate (eGFR) 82 ml/min/1.73 m²
- Participants
- 857 patients
- Exposure
- Highest vs lower quartiles of T90
- Outcome
- Incident very-high-risk CKD (KDIGO risk classification)
Methodological detailssleep-disordered breathing sub-study of DIACORE
- Sleep-disordered breathing sub-study of DIACORE
Main finding
Incident very-high-risk CKD · during follow-up
Odds ratio
2.96
95% CI 1.24–7.07
P = 0.014; p for trend 0.013
By group
T90 highest quartilevs T90 lowest quartile
OR 2.96 (95% CI 1.24–7.07); P = 0.014; p for trend 0.013
As reported in the abstract
- Developed very-high-risk CKD overall
- 72 (8.4%)
Observational data: associations, not effects.
Original publication
Nocturnal hypoxemic burden is associated with worsening prognosis of chronic kidney disease in patients with type 2 diabetes. Cardiovasc Diabetol. Published 31 August 2025. doi:10.
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