Obstructive sleep apnoea is associated with accelerated progression of diabetic kidney disease
Main finding · CKD progression (eGFR decline >50% or RRT)Result — go to the resultAdjusted hazard ratio 3.4 95% CI 1.3–9.1Authors' conclusion
Our results suggest OSA to be an important and independent contributor to the progression of DKD.
Study context
- Population
- Persons with T2D and DKD, estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m² (not on RRT) and elevated urine albumin-creatinine ratioabout 120 evaluated
- Participants
- 120 persons
- Exposure
- Moderate-to-severe obstructive sleep apnoea (OSA) vs no OSA
- OSAn = 36
- Non-OSAn = 41reference
- Outcome
- CKD progression (eGFR decline >50% or RRT)
- Follow-up
- Median 3.2 years from index
Methodological detailsportable home sleep testing (ApneaLink+)
- Portable home sleep testing (ApneaLink+)
Main finding
As reported in the abstract
Adjusted hazard ratio
3.4
95% CI 1.3–9.1
OSAvs Non-OSA
aHR 3.4 (95% CI 1.3–9.1)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| CKD progression or death | 3.2 (1.3–7.7) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| eGFR decline from −5 years to end-of-follow-up (adjusted for age, sex and UACR at −5 years)Larger decline with OSA | P = 0.016 |
eGFR at index
- eGFR comparable between groups at index (32.2 vs. 32.9 mL/min/1.73 m²); OSA had higher body mass index (BMI) and urine albumin-creatinine ratio (UACR)
Original publication
Obstructive sleep apnoea is associated with accelerated progression of diabetic kidney disease. Diabet Med. Published 23 April 2026. doi:10.
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