Association of various insulin resistance surrogate markers with mortality risk in critically ill patients with ischemic stroke: a retrospective cohort study
Authors' conclusion
Multiple IR surrogate markers independently predict in-hospital mortality in critically ill patients with ischemic stroke. Incorporation of these indices into risk stratification may facilitate early identification and targeted intervention for high-risk individuals.
Study context
- Population
- Critically ill patients with ischemic stroke admitted to the intensive care unit (ICU) (eICU-CRD database)
- Participants
- 1,709 patients
- Exposure
- Quartiles of 8 insulin resistance (IR) surrogate markers
- Outcome
- In-hospital mortality
Methodological detailseICU-CRD database
- eICU-CRD database
Main finding
As reported in the abstract
- Deaths
- 437
- In-hospital mortality rate
- 25.57%
- TyG-derived indices, TG-HDL, METS-IR, AIP and CHG positively correlated with mortality; SPISE inversely associated
- all P for trend < 0.05
Observational data: associations, not effects.
Further findings
Kaplan-Meier and restricted cubic spline (RCS) analyses
- Kaplan-Meier curves confirmed associations between the 8 IR surrogate markers and in-hospital mortality
- Nonlinear relationships of SPISE, TG-HDL, METS-IR, TyG-BMI, TyG-RC, CHG with all-cause mortality (RCS)
Original publication
Association of various insulin resistance surrogate markers with mortality risk in critically ill patients with ischemic stroke: a retrospective cohort study. Cardiovasc Diabetol. Published 21 April 2026. doi:10.
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