Diabetes complications

Prognostic significance of the stress hyperglycemia ratio in critically ill patients

Cardiovasc DiabetolPublished Cohort study

An erratum to this article was published (Cardiovasc Diabetol, 6 Dec 2024 ↗)

Authors' conclusion

There was a U-shaped association between SHR and short- and long-term mortality in critical ill patients, and the inflection point of SHR for poor prognosis was identified at an SHR value of 0.96.

Study context

Population
Patients admitted to the intensive care unit (ICU)
Participants
8,978 patients
Exposure
Stress hyperglycemia ratio (SHR) categories and SHR as a continuous variable vs mortality
Outcome
In-hospital and 1-year all-cause mortality
Methodological detailsSHR categorized into uniform groups; logistic or Cox regression; restricted cubic spline analysis
  • SHR categorized into uniform groups; logistic or Cox regression; restricted cubic spline analysis

Main finding

As reported in the abstract

In-hospital mortality
825 (9.2%)
Died within 1-year follow-up
3,130 (34.9%)
Adverse events minimized within SHR range
0.75-0.99
In-hospital mortality per 0.25 increase in SHR, OR
1.34 (1.25-1.44) (95% CI)
In-hospital mortality per 0.25 decrease in SHR within 0.75-0.99 range, OR
1.38 (1.10-1.75) (95% CI)

Observational data: associations, not effects.

Original publication

Prognostic significance of the stress hyperglycemia ratio in critically ill patients. Cardiovasc Diabetol. Published 13 October 2023. doi:10.1186/s12933-023-02005-0

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