Association between stress hyperglycemia ratio index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database
Authors' conclusion
In critically ill patients with AF, higher levels of the SHR index are significantly associated with an increased risk of all-cause mortality at 30 days, 90 days, 180 days, and 365 days. The SHR index may serve as a valid indicator for assessing the severity and guiding the treatment of AF patients in the ICU.
Study context
- Population
- Critically ill patients with atrial fibrillation (AF) at ICU admission, MIMIC-IV database; mean age 63.12 years, 59.58% male
- Participants
- 1,685 patients
- Exposure
- Stress hyperglycemia ratio (SHR) index above vs below inflection point
- Outcome
- All-cause mortality
- Follow-up
- 30 days and 365 days
Methodological detailsMIMIC-IV database, SHR quartiles, Cox proportional-hazards regression, restricted cubic splines
- MIMIC-IV database
- SHR quartiles
- Cox proportional-hazards regression
- Restricted cubic splines
Main finding
As reported in the abstract
SHR above inflection point vs SHR below inflection pointHazard ratio (95% CI)
30-day all-cause mortality; inflection point 0.73
1.699(1.336–2.159)
365-day all-cause mortality; inflection point 0.76
1.616(1.345–1.942)
- Higher SHR associated with increased mortality at 30, 90, 180 and 365 days (Kaplan-Meier)
- log-rank P < 0.01
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality at 90 and 180 days
- Higher SHR associated with increased mortality; risk significantly higher in highest quartile
Original publication
Association between stress hyperglycemia ratio index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study using the MIMIC-IV database. Cardiovasc Diabetol. Published 14 October 2024. doi:10.
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